On or Off a GLP-1: We Ranked The Top 5 Supplements That Help You Lose Weight and Get In Shape

Are You Making The #1 GLP-1 Mistake That Leaves Millions of Women Skinny Fat at Their Goal Weight?

On or Off a GLP-1: We Ranked The Top 5 Supplements That Help You Lose Weight and Get In Shape

Why do some women who take a GLP-1 end up lean, toned and snatched, while others end up skinny fat, deflated and weak?

Take two identical twins.

Same genes. Same GLP-1, same dose, started the same week. 

The only difference? The second sister made the #1 mistake that thousands of women are making every day while on a GLP-1.

Twelve weeks later, both sisters had lost exactly 30 pounds. 

But the scale doesn't tell the full story...

The first sister looks incredible. Her arms are toned and tight, her butt is round and lifted, and her stomach is flat and firm. She's wearing sleeveless tops again, and friends keep asking if she's hired a trainer.

The second sister's arms are soft and saggy, and they keep jiggling after she stops waving. Her butt has gone flat, and her stomach is smaller but still squishy. In photos, she looks tired and older than she is. 

So what happened?

Why Up to 40% of the Weight You Lose on a GLP-1 Is Muscle

When you eat less on a GLP-1, your body pulls energy from wherever it can, and that includes your muscle. 


Studies show that up to 40% of the weight lost on GLP-1 medications can come from lean mass.

That muscle is what makes your arms look toned, your glutes round and lifted and your stomach firm. That's what "skinny fat" really is.

How We Ranked

We reviewed over 30 of the most popular supplements women take on GLP-1s. We checked lab results, ingredients, dosing and customer reviews.

Our #1 test was simple: does it help you keep your shape and strength while the weight comes off? For every creatine product, we also checked whether it actually contained the dose on the label, because many don't.

Here's how all five ranked.

Advertising Disclosure

Fitness Addiction is owned and operated by the same company that owns certain products featured on this website, including the products ranked number one. In addition, we may receive compensation from certain companies whose products are featured on this website when you purchase a product using the links on this website.

TOP 5 SUPPLEMENTS FOR WOMEN ON GLP-1s IN 2026

#1
9.9/10

Creatine is the most researched sports supplement in the world, with over 1,000 peer-reviewed studies behind it. OMNI packs 3g of pure creatine monohydrate per serving, verified by Eurofins and NSF-certified. 3 gummies that taste like a gushers. It's the easiest way we found to refill your muscles' fuel every day, even on days you can barely eat.

PROS

  • Combats GLP-1 muscle loss: creatine is the most studied supplement for preserving lean mass during caloric deficit
  • Supports cellular energy (ATP) production critical when eating less on GLP-1 medications
  • Shown to help you maintain muscle during weight loss
  • Supports bone mineral density - especially important as rapid weight loss can reduce bone density
  • Boosts cognitive function, focus, and mental clarity - combats the brain fog some GLP-1 users report
  • 4000+ verified 5-star reviews from users praising noticeable results
  • Made with premium ingredients in the USA
  • Backed by a 30-day satisfaction guarantee
  • Formulated By a Real U.S Surgeon
  • Delicious Watermelon & Peach flavor 

CONS

  • With +17 million people on GLP-1, demand occasionally leads to limited stock availability
WINNER
OMNI Creatine Gummies
Overall Ranking A+
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Our Review:

OMNI Creatine Gummies earned our #1 spot because they target the main reason women end up skinny fat on a GLP-1: muscle loss. 

Each serving of three gummies delivers a full clinical 3g dose of creatine monohydrate, the exact form used in the research.

Keeps your shape while the weight comes off. Creatine helps your muscles produce the energy they run on (ATP) and helps your body hold onto lean muscle, even in a calorie deficit. That's the muscle that keeps your arms toned and your glutes full and lifted, whether you're on Ozempic, Wegovy, Mounjaro or Zepbound.

Keeps you strong with zero extra effort. Creatine supports muscle strength and power, so everyday things like carrying groceries, climbing stairs and lifting luggage feel easier again. All it takes is three gummies a day.

Lean and firm, never bulky. Creatine has a reputation as a bodybuilder supplement, but building bulky muscle takes years of heavy lifting and a big calorie surplus. On a GLP-1, you're eating less. Creatine helps you hold onto the muscle you already have, and that muscle is what makes you look firm instead of flat.

Bonus benefits. Fast weight loss is linked to weaker bones, and studies show creatine plus resistance training supports bone health better than training alone. Creatine also supports memory, focus and mental energy when you're eating less, which helps with the brain fog many GLP-1 users report.

Why OMNI over other creatine gummies? Independent testing has found that many creatine gummies on the market contain far less creatine than their labels claim. Some are basically candy. OMNI has every batch third-party certified by Eurofins, so you get the full dose your muscles need. The gummies are easy on the stomach, taste great and need no powder or shaker bottle. 

They're also non-GMO and free of artificial colors, sweeteners and fillers.

PROS

  • 5,000 IU (125 mcg) per capsule - clinically effective dose to correct deficiency
  • Critical for GLP-1 users: reduced food intake often leads to vitamin D deficiency
  • Supports calcium absorption and bone density - essential during rapid weight loss
  • Hypoallergenic, gluten-free, and non-GMO - clean formula with no unnecessary fillers

CONS

  • Requires consistent daily use for 4-8 weeks to see meaningful blood level changes
  • Premium price compared to generic vitamin D brands
  • Fat-soluble vitamin - should be taken with a meal containing fat for best absorption
Fiber
Overall Ranking B
VISIT SITE

PROS

  • Directly addresses GLP-1 GI side effects
  • Supports heart health
  • 300 capsules per bottle - excellent value and convenient capsule form

CONS

  • Requires drinking plenty of water - inadequate hydration can cause bloating
  • May need to start with a lower dose and gradually increase to avoid gas

PROS

  • 20g plant-based pea protein per serving 
  • 0g sugar
  • Traceable ingredients with full supply chain transparency

CONS

  • Premium price point at ~$2.13/serving - one of the more expensive proteins
  • Only 2 flavor options available

PROS

  • Vegan DHA + EPA sourced from microalgae
  • Supports heart and brain health
  • Anti-inflammatory properties
  • Small, easy-to-swallow vegan capsules

CONS

  • Premium price for an algae-based omega-3 supplement
  • Lower total EPA/DHA per serving compared to fish-based alternatives
FINAL RANKING

The 5 Best Supplements For GLP-1 Users:

If you want to lose the weight on your GLP-1 without losing your shape, OMNI is the one. It’s the only product on our list built to protect your muscle, with at least 3g of third-party tested creatine per serving, in a gummy you’ll actually look forward to every morning.

Why are OMNI Creatine Gummies ranked the #1 supplement for GLP-1 users?

OMNI scored highest across every category we reviewed - ingredient quality, clinical dosing, taste, convenience, and customer satisfaction. The #1 concern for GLP-1 users is muscle loss, and creatine monohydrate is the single most effective supplement for preserving lean muscle during caloric deficit. OMNI delivers a full clinical dose in a gummy format that's easy on sensitive stomachs, every batch is third-party tested by Eurofins, and the formula is free of artificial dyes, fillers, and sugar. No other product matched that combination of efficacy, purity, and ease of use for GLP-1 users.

Why do I need supplements while on GLP-1 medications?

GLP-1 works by reducing appetite and slowing gastric emptying. While incredibly effective for weight loss, this means you're eating significantly less food - and getting fewer nutrients. Research shows that up to 40% of weight lost on GLP-1s can come from lean muscle, not fat. Targeted supplementation helps preserve muscle mass, maintain bone density, support digestive health, and fill nutritional gaps that smaller meals can't cover.

Will creatine cause weight gain while I'm trying to lose weight on GLP-1s?

No. Some users may see a small initial increase on the scale (1-3 lbs) from intracellular water retention in the muscles - this is not fat gain and actually indicates the creatine is working. This water is stored inside your muscle cells, which supports performance and lean muscle preservation. It does not cause bloating or puffiness, and it stabilizes within the first week. The muscle you preserve with creatine actually supports a healthier metabolism long-term.

Can I take all of these supplements together while on GLP-1 medication?

Yes! All five supplements on this list are safe to take together and alongside GLP-1 medications. However, we recommend spacing them throughout the day - take fiber at least 2 hours apart from other supplements and medications to avoid interference with absorption. Always consult your prescribing physician before starting any new supplement regimen.

What's OMNI's return policy and shipping speed?

OMNI is backed by a 30-day satisfaction guarantee, so you can try it risk-free. Shipping is free on first order, and most customers receive their gummies within 3-5 business days.

OUR #1 Pick For GLP-1 Users

Lose the Weight. OMNI Helps You Keep Your Shape.

Think about your next 12 weeks. The scale will keep dropping. The real question is what you’ll see in the mirror when it does.

Toned arms, a round, lifted butt and a flat, firm stomach? Or the same weight loss, just softer, flatter and weaker?

Muscle is far easier to keep than it is to rebuild later. OMNI is the simplest way we found to keep yours. 

Three doctor-formulated gummies a day give you 3g of pure creatine monohydrate, with every batch third-party tested and no sugar alcohols or bloating fillers. 

DOCTOR FORMULATED

OMNI Creatine Gummies

by OMNI Creatine

  • Tastes Like Gushers 
  • Every Batch Lab Tested
  • 30-Day Money-Back Guarantee
OMNI Creatine Gummies
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